In vitro and in vivo antibacterial activities of DW-224a, a new fluoronaphthyridone.
نویسندگان
چکیده
DW-224a showed the most potent in vitro activity among the quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, DW-224a was slightly less active than the other fluoroquinolones. The in vivo activities of DW-224a against gram-positive bacteria were more potent than those of other quinolones.
منابع مشابه
In vitro and in vivo antibacterial activities of DW286, a new fluoronaphthyridone antibiotic.
The in vitro and in vivo activities of DW286, a novel fluoronaphthyridone with potent antibacterial activity, were compared with those of ciprofloxacin, gemifloxacin, sparfloxacin, and trovafloxacin. Against gram-positive bacteria, such as Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and Enterococcus faecalis, the in vitro activity of DW286 was stronger than that...
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was prevented completely by DW-224a at concentrations of 1·, 2· and 4· MIC by 24 h, although regrowth occurred in the presence of ciprofloxacin at 1· MIC concentration. DW-224a also showed a dose-dependent bactericidal activity against all test organisms up to 4· the MIC. The MBCs of DW-224a in Mueller–Hinton broth (MHB) were identical to 1·MIC or at most twice the MIC for all strains tested. B...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 50 6 شماره
صفحات -
تاریخ انتشار 2006